NDP antisense RNA 1 (non-protein coding) (NDP-AS1)

NDP antisense RNA 1 (NDP-AS1) is a long noncoding antisense RNA transcribed from the NDP locus on the human genome[3]. This molecule does not encode a protein but may regulate expression of its sense gene through various epigenetic and transcriptional mechanisms common to antisense RNAs. Such RNAs typically act by modulating transcription rates, influencing the methylation or chromatin status of the associated sense gene region, or through RNA-RNA interaction affecting mRNA stability and translation efficiency[1][2][3]. While antisense lncRNAs are often involved in diseases by silencing tumor suppressor genes or modulating disease pathways, there is no published evidence (as of September 2025) that NDP-AS1 itself has a definitive disease role or is a target for drugs. The gene is annotated in genetic databases, but further research is needed to clarify its specific biological and clinical significance[3].

Other names

NDP-AS1NDP antisense RNA 1 (non-protein coding)

No drugs target NDP-AS1, but generally, antisense RNAs may be modulated by antisense oligonucleotides (ASOs) to downregulate or alter gene expression