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NECAP endocytosis associated 1 pseudogene 2 (NECAP1P2) is classified as a pseudogene that shares sequence similarities with the functional NECAP1 gene but is not transcribed or translated into a functional protein[3]. Pseudogenes, by definition, are not considered receptors, enzymes, transporters, or therapeutic targets, and thus do not participate in canonical biological functions, disease roles, drug interactions, or therapeutic mechanisms. NECAP1P2 is recorded in human gene databases such as GeneCards (HGNC: 43913, NCBI Gene: 106479026), but no evidence indicates it has any direct biological, pathophysiological, or pharmacological relevance[3]. NECAP1, the protein-coding gene with which this pseudogene shares homology, is involved in clathrin-mediated endocytosis and neurological disease when mutated[1][2][4][5]. However, NECAP1P2 itself does not encode any protein and is not involved in these processes. NECAP1P2 is a pseudogene and not a druggable or biological target. It has no known protein product, function, disease association, or drug interactions[3].
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