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Target intelligence / Profile preview
Nectin cell adhesion molecule 4 (Nectin-4)
- Target
- Nectin-4
- Molecular classification
- Cell adhesion molecule, Immunoglobulin-like protein, Transmembrane protein
01
Overview
Nectin-4 is a cell adhesion molecule belonging to the nectin family. It mediates calcium-independent cell-cell adhesion and interacts with the actin cytoskeleton. While its expression is limited in normal adult tissues, it is frequently overexpressed in various cancers, promoting tumor progression and metastasis, making it a therapeutic target. It is the target of antibody-drug conjugates such as enfortumab vedotin.
- Other names
- PVRL4Poliovirus receptor-related protein 4
02
Mechanism of action
Antibody-drug conjugate targeting Nectin-4, delivering a cytotoxic payload upon internalization.
03
Biological functions
Cell-cell adhesionActin cytoskeleton remodelingCell junction formationSignal transductionAngiogenesisCell proliferationCell migrationEpithelial-mesenchymal transition (EMT)
04
Disease associations
CancerUrothelial carcinomaBreast cancerLung cancerColorectal cancerPancreatic cancerOvarian cancerOral squamous cell carcinoma
05
Safety considerations
Potential for off-target effects due to Nectin-4 expression in some normal tissuesToxicities associated with the cytotoxic payload of antibody-drug conjugates
06
Interacting drugs
Enfortumab vedotin
07
Biomarkers
Nectin-4 expression levels in tumor tissue
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