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NECTIN1 antisense RNA 1 (NECTIN1-AS1) is a lncRNA gene located antisense to the NECTIN1 (nectin cell adhesion molecule 1) gene on chromosome 11q23.3[2][4][6]. It is classified as a non-coding RNA and does not encode a protein. The function, biological roles, and disease associations of NECTIN1-AS1 remain poorly characterized as of current genomic databases. It is primarily noted for its genomic localization relative to NECTIN1, which is a protein-coding gene involved in cell adhesion and several developmental syndromes; however, no direct functional, therapeutic, or clinical roles for NECTIN1-AS1 have been established. NECTIN1-AS1 is not known to be a therapeutic target, nor is it currently associated with pharmacological interventions[4][6]. NECTIN1-AS1 should not be confused with NECTIN1 (Nectin cell adhesion molecule 1), which is a well-studied cell adhesion protein and receptor for herpesviruses[1][7]. NECTIN1-AS1 itself is not a direct therapeutic target, enzyme, or receptor; it is a non-coding RNA[2][4][6]. No therapeutics, biomarkers, or safety concerns have been described for this RNA, and its biological roles are speculative pending further research.
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