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NECTIN3 antisense RNA 1 (NECTIN3-AS1)
- Target
- NECTIN3-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense_lncRNA, Non-coding RNA
01
Overview
NECTIN3 antisense RNA 1 (NECTIN3-AS1) is a long non-coding RNA gene located on chromosome 3 (hg38: chr3:111045388-111071553), transcribed from the negative strand[2]. It overlaps with the NECTIN3 (PVRL3) gene in an antisense orientation. NECTIN3-AS1 does not encode a protein, as confirmed by its lack of protein-coding potential in multiple prediction algorithms[2]. Its sequence has three exons and is classified as an antisense_lncRNA, most likely functioning by regulating its endogenous sense pair (NECTIN3/PVRL3) at the RNA level. General properties of antisense lncRNAs include the ability to modulate transcription, RNA stability, and sometimes translation of the overlapping sense gene, but there is currently no literature describing the specific function of NECTIN3-AS1[2][6].
- Other names
- PVRL3-AS1NONHSAT091136ENSG00000242242ENST00000491709OTTHUMG00000159244ENST00000491709.1ENST00000491709.5
02
Biological functions
Likely gene expression regulation via antisense mechanism (typical of antisense lncRNAs, often affecting sense gene transcript stability, processing, or translation in *cis* or *trans*[2][6])Other (Specific mechanism for NECTIN3-AS1 is uncharacterized; see below)
03
Disease associations
Other (No identified, specific disease association for NECTIN3-AS1 itself; unlike some antisense lncRNAs, there are currently no reports directly implicating NECTIN3-AS1 in cancer, inflammation, or other major disease categories in indexed literature[1][2].)
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