NEDD4 family-interacting protein 2 (NDFIP2)

NEDD4 family-interacting protein 2 (NDFIP2) is a small transmembrane adaptor protein that contains PY motifs and serves as a critical regulator of NEDD4 family E3 ubiquitin ligases. Through binding its PPxY motifs to the WW domains of these ligases, NDFIP2 relieves their autoinhibitory interactions, activating their catalytic function and promoting ubiquitination of various substrate proteins[1][2][3]. This activity impacts key cellular processes, including the regulation of ion channel surface expression (notably KCNH2/hERG), protein trafficking in epithelial cells and T lymphocytes, and broader signaling events in Akt and JNK pathways[1][3][5]. NDFIP2 also acts as a scaffold modulating receptor-mediated signal transduction and controlling protein stability, with physical and functional links to EGF receptor, PTEN, and Src family kinases. Its roles implicate it in the regulation of cell proliferation, differentiation, and homeostasis, as well as pathologies such as cancer and inflammation[1][2][3][5].

Other names

NDFIP2N4WBP5AKIAA1165NEDD4 WW domain-binding protein 5A

No explicit drugs target NDFIP2 directly in the provided results; if targeted in the future, likely mechanisms would include: - Modulation of E3 ligase activity for protein ubiquitination - Altering cell surface receptor or ion channel degradation