NEDD8 ultimate buster 1 (NUB1)

NEDD8 ultimate buster 1 (NUB1) is a ubiquitin-like protein-interacting adaptor that functions primarily as a negative regulator of the NEDD8 conjugation system by recruiting NEDD8, FAT10, and their conjugates to the proteasome for degradation[1][2][3]. It contains an N-terminal ubiquitin-like (UBL) domain and multiple C-terminal ubiquitin-associated (UBA) domains[1][2]. Expression of NUB1 is interferon-inducible and is detected in all tissues[2]. NUB1 plays a role in pathways relevant to cancer (via p53 regulation), neurodegeneration (by suppressing protein aggregates characteristic of synucleinopathies and Huntington disease), and retinal degeneration (Leber congenital amaurosis via AIPL1 interaction)[1][2][3]. NUB1 accumulates in pathologic inclusions (Lewy bodies and glial cytoplasmic inclusions) in neurodegenerative diseases[1][3]. No approved drugs directly target NUB1, but it is considered a regulator in key protein degradation pathways and has been suggested as a therapeutic target in neurodegeneration and cancer[2].

Other names

NUB1NUB1LNYREN18BS4Negative regulator of ubiquitin-like proteins 1Renal carcinoma antigen NY-REN-18

Negative regulation of neddylated proteins via proteasomal targeting. Down-regulation of synphilin-1 and mutant huntingtin through polyubiquitination and proteasomal degradation. Facilitates proteasomal degradation of NEDD8, UBD, FAT10, and their conjugates.