NEFH pseudogene 2 (NEFHP2)

NEFH pseudogene 2 (NEFHP2) is a member of the pseudogene family located on human chromosome 20 (hg38: chr20:41997131-41999397)[1]. Pseudogenes are defective copies of functional genes, often arising by duplication or retrotransposition, that no longer encode a functional protein or produce a detectable gene product[7][8]. NEFHP2 is homologous to the **neurofilament heavy polypeptide gene (NEFH)**, which is a structural protein in neurons, but NEFHP2 itself is non-functional and has no verified protein-coding capacity, signaling property, or known biological role in disease modulation[6][7][8]. Therefore, it is not a therapeutic target and should not be confused with the functional NEFH gene. This entry represents a **non-functional pseudogene** and does **not** meet criteria for drug targeting, biomarker use, or therapeutic intervention[6][7][8].

Other names

neurofilament heavy chain pseudogeneNEFH pseudogene 2