Negative-pressure induced mechanical stimulation

Negative-pressure induced mechanical stimulation describes the application of controlled negative pressure (suction or vacuum) to tissues or cells to induce mechanical stress, with resulting biological and therapeutic effects. In clinical and preclinical settings, this approach is most commonly applied during negative pressure wound therapy (NPWT) or experimental protocols aiming to enhance cell proliferation, angiogenesis, osteogenic differentiation, and tissue remodeling. Mechanistically, negative pressure creates mechanical deformation, draws wound edges together, stimulates cell signaling pathways (such as those involving collagen type I, osteonectin, or sodium channel mechanosensitivity), and can induce favorable microenvironmental changes that promote healing, bone formation, or scar remodeling[1][2][3][4][6][7]. This is a procedure or modality, not a molecular target. This term should not be considered a canonical molecule or drug target; instead, it refers to a physical/mechanical intervention and thus should be flagged as incorrect in settings where a molecular target is required.

Other names

Negative-pressure mechanical stimulationNegative-pressure therapyNegative pressure wound therapy (NPWT)