Neighbor of BRCA1 gene 1 pseudogene

ENSG00000285057, known as the Neighbor of BRCA1 gene 1 pseudogene, is a **non-functional genomic sequence** resembling the NBR1 gene but lacking the capacity to encode a functional protein due to disruptive mutations or deletions typical of pseudogenes[1][7]. It resides near the genuine NBR1 gene on chromosome 17q21, itself positioned adjacent to the BRCA1 gene, but does not produce a functional NBR1 protein. There is **no evidence** that it serves as a direct therapeutic target or has a described biological or disease role. The term "pseudogene" indicates its major classification, distinguishing it from protein-coding or regulatory targets commonly considered in drug discovery[1][7]. If you require information on the functional Neighbor of BRCA1 gene 1 (*NBR1*, ENSG00000188554), which is involved in selective autophagy and implicated in cancer biology, refer instead to the protein-coding gene, not the pseudogene[6][10].

Other names

NBR1 pseudogeneNeighbor of BRCA1 gene 1 (NBR1) pseudogene