Neighbor of BRCA1 lncRNA 2 (NBR2)

NBR2 (Neighbor of BRCA1 lncRNA 2) is a long non-coding RNA gene located adjacent to the tumor suppressor gene BRCA1 on chromosome 17. Unlike its neighboring gene NBR1, which encodes a protein, NBR2 does not code for a functional protein, and its transcripts are instead classified as lncRNAs typically longer than 200 nucleotides. NBR2 is regulated independently from BRCA1 but shares a bi-directional promoter with it. NBR2 is induced in response to glucose starvation and cellular energy stress. It acts as a regulator by directly binding and activating AMP-activated protein kinase (AMPK), promoting energy homeostasis, autophagy, and exerting tumor suppressor functions. Its downregulation is associated with increased tumor proliferation and poor prognosis in several cancers. There is no compelling evidence that NBR2 is directly druggable or a current focus for therapeutics, but it represents a novel example of an lncRNA participating in essential metabolic and oncogenic regulatory pathways.

Other names

NCRNA00192Non-protein coding RNA 192Neighbor of BRCA1 gene 2 (non-protein coding)NBR2 (official abbreviation)

Not applicable. Since NBR2 is not a therapeutic target for any known drugs, there are no mechanisms of action related to drug interactions. However, at the molecular level, NBR2 directly binds to and activates AMPK, a central metabolic regulator.