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Neisseria adhesin A protein (NadA)
- Target
- NadA
- Molecular classification
- Trimeric autotransporter adhesin, Adhesin, Oligomeric coiled-coil adhesin (OCA)
01
Overview
Neisseria adhesin A (NadA) is a trimeric autotransporter protein found in a subset of Neisseria meningitidis strains. NadA mediates adhesion to human epithelial cells and myeloid cells, facilitating colonization and infection. It is highly immunogenic and is a component of the multi-component vaccine Bexsero against serogroup B N. meningitidis.
02
Mechanism of action
Adhesion inhibition, Antibody-mediated neutralization
03
Biological functions
AdhesionInvasionImmune response modulationColonization
04
Disease associations
InfectionMeningococcal disease
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