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Target intelligence / Profile preview
Neisseria gonorrhoeae (N. gonorrhoeae)
- Target
- N. gonorrhoeae
- Molecular classification
- Bacterium, Gram-negative bacterium, Diplococcus
01
Overview
Neisseria gonorrhoeae is a Gram-negative, coffee-bean shaped diplococcus bacterium and the causative agent of gonorrhoea, a common sexually transmitted infection. It exhibits several virulence factors including lipooligosaccharide (LOS), fimbriae/pili, outer membrane proteins (PorA/PorB, Protein III), and β-lactamase. The bacterium is capable of rapid antimicrobial resistance development and immune evasion, posing a significant public health threat due to its high prevalence and potential for untreatable infections.
- Other names
- Gonococcus
02
Mechanism of action
N/A
03
Biological functions
PathogenesisInfectionColonizationImmune evasionAntimicrobial resistance
04
Disease associations
GonorrhoeaSexually transmitted infectionPelvic inflammatory diseaseEpididymitisSeptic arthritisEndocarditisEctopic pregnancyNeonatal eye infectionsInfertilityIncreased HIV risk
05
Safety considerations
Antimicrobial resistanceTreatment failureHigh prevalenceAsymptomatic infectionsSerious complications (infertility, ectopic pregnancy, disseminated infection)
06
Interacting drugs
Penicillins
4 more in the full profile.
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