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Neisseria meningitidis Capsular Polysaccharide

Molecular classification: Polysaccharide, Capsular Polysaccharide

Overview

The capsular polysaccharide of *Neisseria meningitidis* is an extracellular carbohydrate layer essential to bacterial virulence and survival within humans. Its structural diversity underlies both epidemiological classification into serogroups and serves as a principal target for current vaccines against invasive disease caused by this pathogen.

Other names: Meningococcal Capsular PolysaccharideCPSGroup A Capsular PolysaccharideGroup B Capsular PolysaccharideGroup C Capsular PolysaccharideGroup W Capsular PolysaccharideGroup X Capsular PolysaccharideGroup Y Capsular Polysaccharide

Mechanism of action

Antibody-mediated opsonization and complement activation following vaccine-induced antibody production.

Biological functions

Immune evasionComplement resistancePhagocytosis inhibitionBacterial virulenceAdhesion

Disease associations

MeningitisSepticemiaInvasive Meningococcal DiseaseInfection

Safety considerations

Poor immunogenicity of some serogroups (e.g., Group B)Molecular mimicry leading to autoimmunity (Group B)Capsule switching leading to vaccine escapeLimited efficacy in certain populations (e.g., infants)

Interacting drugs

Conjugate vaccines (e.g., MenACWY)

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