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Neisseria meningitidis Capsular Polysaccharide (Serogroups A, C, W, Y) (NmCPS (A, C, W, Y))

Target: NmCPS (A, C, W, Y)
Molecular classification: Polysaccharide, Capsular Polysaccharide, Antigen

Overview

Neisseria meningitidis capsular polysaccharides from serogroups A, C, W/W135, and Y are key virulence factors and major antigens used in quadrivalent conjugate vaccines. The capsule protects the bacteria from host immune responses, preventing phagocytosis and complement-mediated killing. These polysaccharides are composed of distinct repeating units: O-acetylated N-acetyl-D-mannosamine phosphate for serogroup A, polysialic acid for serogroup C, sialic acid-galactose for serogroup W, and sialic acid-glucose for serogroup Y. The genetic determinants for capsule biosynthesis reside within the cps locus. These polysaccharides are targets for vaccines and important markers for epidemiological surveillance.

Other names: N. meningitidis serogroup A capsular polysaccharideN. meningitidis serogroup C capsular polysaccharideN. meningitidis serogroup W capsular polysaccharideN. meningitidis serogroup Y capsular polysaccharideMenA capsular polysaccharideMenC capsular polysaccharideMenW capsular polysaccharideMenY capsular polysaccharideSerogroup A capsular polysaccharideSerogroup C capsular polysaccharideSerogroup W capsular polysaccharideSerogroup Y capsular polysaccharide

Mechanism of action

Induction of antibodies against capsular polysaccharides, leading to opsonization and complement-mediated killing of N. meningitidis

Biological functions

Immune evasionProtection from phagocytosisProtection from complement-mediated killingVirulence factor

Disease associations

InfectionMeningitisSepticemia

Safety considerations

Injection site reactionsRare cases of Guillain-Barré syndromeAllergic reactions

Interacting drugs

MenACWY conjugate vaccines

1 more in the full profile.

Biomarkers

Antibody titers against serogroups A, C, W, and YSerogroup-specific antibody levels post-vaccination

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