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Neisseria meningitidis capsular polysaccharide group Y
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The Neisseria meningitidis group Y capsular polysaccharide is a linear heteropolymer composed primarily of alternating D-glucose and N-acetylneuraminic acid residues with specific glycosidic linkages. Its synthesis involves dedicated genes within the cps locus on the bacterial chromosome. This structure not only defines serogroup specificity but also underpins both pathogenesis—by protecting bacteria from host defenses—and prevention strategies through its inclusion in effective conjugate vaccines against invasive disease caused by this organism.
- Other names
- Group Y capsular polysaccharideSerogroup Y capsuleN. meningitidis serogroup Y capsular polysaccharide
02
Mechanism of action
Vaccines induce antibody production that opsonizes bacteria for phagocytosis and complement-mediated lysis.
03
Biological functions
Immune evasionVirulence factorProtection from complement-mediated killingProtection from phagocytosis
04
Disease associations
Invasive meningococcal diseaseMeningitisSepticemia
05
Safety considerations
Capsule switching may reduce vaccine effectiveness.Limited protection against strains expressing different capsular serogroups.
06
Interacting drugs
Quadrivalent conjugate vaccines (A, C, W, Y)
1 more in the full profile.
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