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Target intelligence / Profile preview
Neisseria meningitidis Capsular Polysaccharide Serogroup C (CPS Serogroup C)
- Target
- CPS Serogroup C
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Bacterial surface antigen
01
Overview
The Neisseria meningitidis capsular polysaccharide serogroup C is an α(2→9)-linked sialic acid polymer encoded by genes within the cps locus. It serves as both a major virulence determinant—enabling immune evasion—and as an effective vaccine target due to its role in pathogenesis and immunogenicity against invasive disease caused by this pathogen.
- Other names
- Serogroup C Capsular PolysaccharideN. meningitidis Serogroup C Capsule(α2→9)-linked sialic acid polymer
02
Mechanism of action
Antibody-mediated opsonization and complement activation following vaccination; Block capsule biosynthesis
03
Biological functions
Immune evasionVirulence factorCapsule biosynthesisProtection from phagocytosisProtection from complement-mediated killing
04
Disease associations
MeningitisSepsisInvasive meningococcal disease
05
Safety considerations
Vaccine side effects (e.g., injection site reactions)Potential for capsular switchingLimited efficacy against all strains
06
Interacting drugs
Serogroup C conjugate vaccines
3 more in the full profile.
07
Biomarkers
Anti-capsular polysaccharide antibodiesCapsular polysaccharide levels in bacterial isolates
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