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Target intelligence / Profile preview
Neisseria meningitidis capsular polysaccharide serogroup W (W135) (Serogroup W135)
- Target
- Serogroup W135
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The capsular polysaccharide of Neisseria meningitidis serogroup W (W135) is a major virulence factor and a key target for conjugate vaccines. It consists of a sialic acid–galactose polymer and is crucial for immune evasion. Antibodies generated against this polysaccharide via vaccination provide protection against invasive meningococcal disease caused by serogroup W135.
- Other names
- N. meningitidis serogroup W135 capsular polysaccharideSerogroup WW135 capsular polysaccharide
02
Mechanism of action
Antibody-mediated complement activation and opsonization
03
Biological functions
Immune evasionVirulence factorAntigenic determinant
04
Disease associations
Invasive meningococcal diseaseMeningitisSepticemia
05
Interacting drugs
Menactra
3 more in the full profile.
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