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Target intelligence / Profile preview
Neisseria meningitidis Capsular Polysaccharide Serogroup W-135 (W-135 CPS)
- Target
- W-135 CPS
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The capsular polysaccharide of Neisseria meningitidis serogroup W-135 is a major virulence factor responsible for immune evasion and invasive disease. It is the target of conjugate vaccines, which induce protective immunity by stimulating antibody production against this polysaccharide. The W-135 capsule's unique structure, encoded by genes within the *cps* locus, allows for serogroup-specific identification and vaccine development.
- Other names
- Serogroup W-135 capsular polysaccharideNmW-135 CPS
02
Mechanism of action
The W-135 capsular polysaccharide, when presented as a conjugate vaccine, elicits an antibody response in the host that neutralizes the N. meningitidis serogroup W-135 bacteria, preventing infection.
03
Biological functions
Immune evasionProtection against phagocytosisVirulence factorCapsule biosynthesis
04
Disease associations
MeningitisSepticemiaInvasive meningococcal disease
05
Safety considerations
Vaccine-related adverse reactions (e.g., injection site pain, fever)Potential for breakthrough infections despite vaccination
06
Interacting drugs
Menactra (Conjugate Vaccine)
07
Biomarkers
Antibody titers against W-135 capsular polysaccharidePresence of N. meningitidis serogroup W-135 in cerebrospinal fluid or blood
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