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Neisseria meningitidis Capsular Polysaccharide Serogroup Y (Serogroup Y CPS)

Target: Serogroup Y CPS
Molecular classification: Polysaccharide, Capsular Polysaccharide, Bacterial Antigen

Overview

The capsular polysaccharide of Neisseria meningitidis serogroup Y is a complex carbohydrate polymer composed of repeating units of sialic acid (N-acetylneuraminic acid) and glucose. It is a major virulence factor that protects the bacterium from phagocytosis and complement-mediated killing. It is the target of MenACWY conjugate vaccines, which induce antibodies that provide protection against invasive disease caused by serogroup Y N. meningitidis. The cps locus is responsible for the biosynthesis and surface expression of this capsule.

Other names: N. meningitidis serogroup Y capsuleGroup Y meningococcal polysaccharideSerogroup Y capsular polysaccharideNmY CPS

Mechanism of action

Vaccine-induced antibody production targeting the capsule, leading to complement-mediated killing and opsonization of bacteria.

Biological functions

Capsule formationImmune evasionAdhesionVirulence factor

Disease associations

MeningitisSepticemiaPneumoniaInvasive Meningococcal Disease

Safety considerations

Vaccine adverse reactions (rare)Limited protection against non-vaccine serogroups

Interacting drugs

MenACWY conjugate vaccines

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