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Target intelligence / Profile preview
Neisseria meningitidis capsular polysaccharide Y (CPS Y)
- Target
- CPS Y
- Molecular classification
- Polysaccharide, Capsular polysaccharide
01
Overview
The capsular polysaccharide of Neisseria meningitidis serogroup Y is a virulence factor composed of repeating units of alternating D-glucose and partially O-acetylated sialic acid residues. It protects the bacteria from phagocytosis and complement-mediated killing, contributing to the pathogenesis of meningitis and septicemia. It is the target antigen for conjugate vaccines against N. meningitidis serogroups A, C, W135, and Y.
- Other names
- Serogroup Y capsular polysaccharideN. meningitidis Y capsule
02
Mechanism of action
Antibodies targeting the capsular polysaccharide induce complement-mediated killing and opsonization.
03
Biological functions
Immune evasionAntiphagocytosisSerum resistanceVirulence factor
04
Disease associations
InfectionMeningitisSepticemia
05
Safety considerations
Capsule switching allows immune evasion.Genetic exchange leading to change in expressed capsule type is important for epidemiology and vaccine strategy considerations.
06
Interacting drugs
Conjugate vaccines (against N. meningitidis serogroups A, C, W135, and Y)
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