Target intelligence / Profile preview

Neisseria meningitidis capsular polysaccharides (serogroup W-135) (None)

Target
None
Molecular classification
Polysaccharide, Capsular Polysaccharide, Antigen
01

Overview

Neisseria meningitidis group W-135 capsular polysaccharide is a surface-expressed carbohydrate polymer crucial for bacterial survival during infection due to its role in immune evasion. It serves as both an epidemiological marker distinguishing this important pathogenic group and as an effective target antigen for current multivalent conjugate vaccines designed to prevent life-threatening infections caused by this organism.

Other names
N. meningitidis serogroup W-135 capsular polysaccharideGroup W-135 capsular polysaccharideW-135 CPS
02

Mechanism of action

Antibody-mediated complement activation; Opsonization; Induction of protective immunity

03

Biological functions

Immune evasionBacterial virulenceCapsule formationAntigen presentation
04

Disease associations

MeningitisSepticemiaInvasive meningococcal diseaseInfection
05

Safety considerations

Hypersensitivity reactions to vaccine componentsInjection site reactions
06

Interacting drugs

Menactra

2 more in the full profile.

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