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Neisseria meningitidis Capsular Polysaccharides (Serogroups A, C, Y, W‑135) (Nm CP (A, C, Y, W-135))

Target: Nm CP (A, C, Y, W-135)
Molecular classification: Polysaccharide, Capsular Polysaccharide, Antigen

Overview

Neisseria meningitidis capsular polysaccharides are the primary virulence factors of this bacterium, contributing to its ability to cause invasive diseases such as meningitis and septicemia. The capsule's chemical structure defines the serogroup, with A, C, Y, and W-135 being among the most clinically relevant. These polysaccharides are targets for vaccine development; vaccines elicit an immune response that protects against infection by promoting opsonization and complement-mediated killing.

Other names: N. meningitidis serogroup A capsular polysaccharideN. meningitidis serogroup C capsular polysaccharideN. meningitidis serogroup Y capsular polysaccharideN. meningitidis serogroup W-135 capsular polysaccharideCPS ACPS CCPS YCPS W-135

Mechanism of action

Vaccines induce antibody production against specific capsular polysaccharides, leading to opsonization and complement-mediated killing of Neisseria meningitidis.

Biological functions

Immune evasionProtection against phagocytosisComplement inhibitionAdhesionVirulence

Disease associations

MeningitisSepticemiaInvasive meningococcal disease

Safety considerations

Injection site reactionsRare cases of Guillain-Barré Syndrome (GBS) following vaccinationLimited efficacy in infants without conjugate vaccines

Interacting drugs

NmVac4-A/C/Y/W-135

1 more in the full profile.

Biomarkers

Antibody titers against capsular polysaccharides (Serogroups A, C, Y, W-135)Capsular polysaccharide detection in cerebrospinal fluid or blood

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