Target intelligence / Profile preview

Neisseria meningitidis Capsular Polysaccharides Serogroup C (MenC CPS)

Target
MenC CPS
Molecular classification
Polysaccharide, Capsular Polysaccharide
01

Overview

The capsular polysaccharide of Neisseria meningitidis serogroup C, composed primarily of α(2→9)-linked N-acetylneuraminic acid, is a critical virulence factor enabling immune evasion. It serves as the primary antigenic target for both polysaccharide and conjugate vaccines aimed at preventing invasive meningococcal disease caused by this serogroup.

Other names
Serogroup C capsular polysaccharideMenC polysaccharideN. meningitidis serogroup C capsule
02

Mechanism of action

Antibody-mediated complement activation and opsonization, induction of long-lasting immunity

03

Biological functions

Immune evasionAnti-phagocytic barrierVirulence factor
04

Disease associations

MeningitisSepticemiaInvasive meningococcal disease
05

Safety considerations

Vaccine side effects (e.g., fever, local reactions)Potential for capsular switching
06

Interacting drugs

Anti-MenC antibodies

4 more in the full profile.

07

Biomarkers

Anti-MenC antibody titersCapsular polysaccharide C presence

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