Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neisseria meningitidis factor H binding protein (fHbp)
- Target
- fHbp
- Molecular classification
- Lipoprotein, Surface antigen
01
Overview
Neisseria meningitidis factor H binding protein (fHbp) is a surface-exposed lipoprotein found on the bacterium *Neisseria meningitidis*, a major cause of bacterial meningitis and sepsis worldwide. fHbp plays a critical role in immune evasion by binding to human complement factor H (CFH), thereby protecting the bacterium from complement-mediated killing. It is an important protective antigen included as a key component in two licensed vaccines against serogroup B *N. meningitidis* (MenB).
- Other names
- gna1870
02
Mechanism of action
Vaccines elicit antibodies that block CFH binding or promote bactericidal activity via complement activation.
03
Biological functions
Complement inhibitionImmune evasionFactor H binding
04
Disease associations
InfectionMeningitisSepsis
05
Safety considerations
Sequence variation among natural isolates necessitates broad coverage strategies for effective vaccination.
06
Interacting drugs
MenB vaccines (Bexsero, Trumenba)
07
Biomarkers
fHbp expression levelsSequence variants
Beyond the preview
Go deeper on Neisseria meningitidis factor H binding protein (fHbp).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neisseria meningitidis factor H binding protein (fHbp).