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Target intelligence / Profile preview
Neisseria meningitidis Group A Capsular Polysaccharide Antigen (NmA CPS)
- Target
- NmA CPS
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Neisseria meningitidis group A capsular polysaccharide antigen is a surface-expressed carbohydrate polymer that forms the capsule of *Neisseria meningitidis* serogroup A. This capsule is the primary virulence factor for this bacterium, enabling it to evade host immune responses and cause invasive diseases such as meningitis and septicemia. It is composed of a homopolymer of O-acetylated, α(1→6)-linked N-acetylmannosamine-1-phosphate (ManNAc-1-P). Vaccines are designed to elicit antibodies against this antigen to promote opsonization and complement-mediated lysis of the bacteria.
- Other names
- Group A Capsular PolysaccharideN. meningitidis serogroup A capsuleSerogroup A polysaccharide
02
Mechanism of action
Antibody-mediated opsonization and complement-mediated lysis
03
Biological functions
Immune evasionVirulence factorSerogroup markerOpsonization target
04
Disease associations
MeningitisSepticemiaInvasive meningococcal disease
05
Safety considerations
Vaccine-related adverse events (rare)Capsule switching leading to vaccine escapeAge-dependent immune response to vaccination
06
Interacting drugs
Menactra
2 more in the full profile.
07
Biomarkers
Anti-NmA CPS antibody titers (vaccine efficacy)Presence of NmA CPS in CSF or blood (diagnosis)
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