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Neisseria meningitidis group A polysaccharide-protein conjugate

Molecular classification: Polysaccharide-protein conjugate, Vaccine antigen

Overview

The Neisseria meningitidis group A polysaccharide-protein conjugate is a vaccine antigen designed to prevent invasive disease caused by *Neisseria meningitidis* serogroup A. This target is the basis for several conjugate vaccines, such as MenAfriVac and components of quadrivalent vaccines (e.g., MenACWY formulations), which have been instrumental in controlling epidemics of meningococcal disease, particularly in Africa’s “meningitis belt”

Mechanism of action

Induces strong antibody-mediated immunity via T-cell dependent pathway

Biological functions

Immune response inductionAntibody productionB cell activationT cell activation

Disease associations

InfectionMeningococcal disease

Interacting drugs

MenAfriVac

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