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Target intelligence / Profile preview
Neisseria meningitidis Group B Outer Membrane Protein (MenB OMP)
- Target
- MenB OMP
- Molecular classification
- Porin, Outer Membrane Protein, Metallopeptidase
01
Overview
Neisseria meningitidis group B outer membrane proteins (OMPs) are key components of the bacterial cell envelope and play crucial roles in nutrient transport, host-pathogen interactions, and immune evasion. These proteins, particularly PorA and PorB, are major targets for vaccine development due to their surface exposure and immunogenicity. OMV-based vaccines containing these proteins have shown efficacy but require careful selection/matching of antigen variants for broad coverage.
- Other names
- Group B OMPPorAPorBNMB0315
02
Mechanism of action
Antibody-mediated bacterial killing, complement activation
03
Biological functions
Nutrient transportHost-pathogen interactionImmune evasionImmune response
04
Disease associations
InfectionMeningitis
05
Safety considerations
Serotype-specific protectionAntigenic variabilityLimited cross-reactivity
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