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Target intelligence / Profile preview
Neisseria meningitidis Group B Surface Antigens (MenB Surface Antigens)
- Target
- MenB Surface Antigens
- Molecular classification
- Polysaccharide, Outer Membrane Protein, Lipooligosaccharide, Adhesin, Iron Acquisition Protein
01
Overview
Neisseria meningitidis group B (MenB) surface antigens are crucial for bacterial pathogenesis and immune evasion. Key antigens include the polysaccharide capsule, outer membrane proteins (PorA, PorB, fHbp, NHBA, NadA), and lipooligosaccharide (LOS). These antigens mediate colonization, immune evasion, and invasion, making them primary targets for vaccine development. Licensed MenB vaccines utilize subcapsular protein antigens to overcome the poor immunogenicity of the capsule.
- Other names
- MenB Surface AntigensGroup B Meningococcal Surface Antigens
02
Mechanism of action
Antibody-mediated bacterial killing, complement activation, opsonization
03
Biological functions
Immune evasionHost cell adhesionIron acquisitionComplement resistanceInnate immune activationInduction of apoptosis
04
Disease associations
MeningitisSepsisInfection
05
Safety considerations
Genetic variability necessitates multicomponent vaccinesPotential for antigenic variation
06
Interacting drugs
Bexsero
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