Target intelligence / Profile preview

Neisseria meningitidis group C capsular polysaccharide–tetanus toxoid conjugate (MenC-TT)

Target: MenC-TT
Molecular classification: Conjugate antigen, Polysaccharide, Toxoid

Overview

The Neisseria meningitidis group C capsular polysaccharide–tetanus toxoid conjugate is a conjugate antigen used in vaccines to prevent invasive disease caused by Neisseria meningitidis serogroup C. It consists of the capsular polysaccharide from N. meningitidis group C covalently linked to tetanus toxoid protein, enhancing immunogenicity, especially in infants and young children. This conjugation converts the polysaccharide into a T-cell dependent antigen, resulting in stronger and longer-lasting immune responses, stimulating the immune system to produce protective antibodies against N. meningitidis group C. It is a key component of combination vaccines like MenQuadfi, Nimenrix and Penbraya.

Other names: Meningococcal C conjugate vaccineGroup C meningococcal conjugate vaccineNeisseria meningitidis serogroup C capsular polysaccharide tetanus toxoid conjugate

Mechanism of action

Induces a protective antibody response against Neisseria meningitidis serogroup C through B-cell and T-cell activation.

Biological functions

ImmunogenAntigen presentationAntibody productionB-cell activationT-cell activation

Disease associations

InfectionInvasive Meningococcal Disease

Safety considerations

Common vaccine-related adverse reactions (e.g., fever, pain at injection site)Hypersensitivity reactions

Interacting drugs

MenQuadfi

2 more in the full profile.

Biomarkers

Anti-MenC antibody titers

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