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Target intelligence / Profile preview
Neisseria meningitidis Group C Polysaccharide Antigen (Group C Polysaccharide)
- Target
- Group C Polysaccharide
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Neisseria meningitidis group C polysaccharide antigen is an essential virulence determinant forming part of the bacterial capsule. Its structure—composed mainly of α(2→9)-linked sialic acids—enables immune evasion. It serves as a critical target for licensed vaccines that prevent invasive disease caused by serogroup C strains through induction of protective antibodies. Genes encoding its biosynthesis and export reside at a defined chromosomal locus termed cps.
- Other names
- N. meningitidis serogroup C capsuleGroup C capsular polysaccharide
02
Mechanism of action
Vaccine antigens stimulate antibody production providing immunity against the corresponding pathogen.
03
Biological functions
Immune evasionVirulenceComplement resistancePhagocytosis inhibition
04
Disease associations
MeningitisMeningococcemiaInvasive meningococcal disease
05
Safety considerations
Vaccine-related adverse reactions (e.g., fever, pain at injection site)
06
Interacting drugs
Menquadfi
3 more in the full profile.
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