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Target intelligence / Profile preview
Neisseria meningitidis Group C Polysaccharide Capsule
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Neisseria meningitidis group C polysaccharide capsule is a surface-expressed carbohydrate structure that serves as the primary virulence factor for this bacterium. The capsule enables the organism to evade host immune responses, particularly by resisting antibody/complement-mediated killing and inhibiting phagocytosis. It is also the key antigenic determinant used to classify N. meningitidis into serogroups, with group C being one of six serogroups (A, B, C, W, X, Y) responsible for most invasive disease in humans. The group C capsular polysaccharide consists of repeating units of O-acetylated (α1→6)-linked N-acetyl-D-mannosamine-1-phosphate.
- Other names
- Neisseria meningitidis Group C Capsular Polysaccharide AntigencsaA-D gene clustermynA-D/sacA-D gene clusters
02
Mechanism of action
Antibodies targeting the capsular polysaccharide promote complement-mediated killing and opsonization.
03
Biological functions
Immune evasionVirulenceSerogroup determinationProtection against phagocytosisComplement resistance
04
Disease associations
InfectionMeningitisSepsis
05
Safety considerations
Capsule switching via genetic recombinationPotential for reduced vaccine efficacy due to capsule switching
06
Interacting drugs
Group C Meningococcal Vaccines (Polysaccharide)
1 more in the full profile.
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