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Neisseria meningitidis group W-135 capsular polysaccharide antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide Antigen
01
Overview
The Neisseria meningitidis group W-135 capsular polysaccharide antigen is a group-specific carbohydrate structure found on the surface of N. meningitidis bacteria belonging to serogroup W-135. This antigen forms part of the bacterium’s capsule, which is a key virulence factor and the basis for serogroup classification. The capsule is composed of polysaccharides that protect N. meningitidis from host immune responses, particularly phagocytosis. For serogroup W-135, the capsular polysaccharide consists primarily of repeating units of sialic acid derivatives. It is a key target for vaccine development against invasive disease.
- Other names
- Meningococcal (group) w-135 capsular polysaccharideNeisseria meningitidis group w-135 capsular antigenMeningococcal polysaccharide vaccine group w–135
02
Mechanism of action
Antibody production against the polysaccharide, leading to opsonization and complement-mediated killing of Neisseria meningitidis group W-135 bacteria.
03
Biological functions
Capsule formationEvasion from host immunityAntigen presentation
04
Disease associations
InfectionMeningitisSepticemia
05
Interacting drugs
Menactra
3 more in the full profile.
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