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Target intelligence / Profile preview
Neisseria meningitidis Group W Capsular Polysaccharide Antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Neisseria meningitidis group W capsular polysaccharide antigen is a surface-expressed carbohydrate polymer that forms the capsule surrounding the bacterium. This capsule is a major virulence determinant, enabling the pathogen to evade host immune responses and cause invasive diseases. It is a key target for vaccines designed to prevent invasive meningococcal disease. Antibodies targeting this antigen confer protection against disease.
- Other names
- Group W capsular polysaccharideNmW CPSN. meningitidis serogroup W polysaccharide
02
Mechanism of action
Vaccines induce production of antibodies that bind to the Group W capsular polysaccharide, promoting complement-mediated killing and/or opsonization and phagocytosis of N. meningitidis bacteria.
03
Biological functions
Immune evasionComplement inhibitionProtection against phagocytosisCapsule formationVirulence factor
04
Disease associations
MeningitisSepticemiaInvasive meningococcal diseaseInfection
05
Safety considerations
Vaccine-related adverse reactions (e.g., injection site pain, fever)Potential for capsule switching or serogroup replacement following vaccination
06
Interacting drugs
MenACWY vaccines (e.g., Nimenrix, Menveo)
1 more in the full profile.
07
Biomarkers
Antibody titers against Group W capsular polysaccharide (for vaccine efficacy)Detection of Group W capsular polysaccharide in clinical samples (for diagnosis)
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