Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neisseria meningitidis Group W135 Capsular Polysaccharide (W135 CPS)
- Target
- W135 CPS
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The *Neisseria meningitidis* group W135 capsular polysaccharide is a high-molecular-weight carbohydrate polymer that forms the outer capsule of *N. meningitidis* serogroup W135. This capsule is a critical virulence factor, enabling the bacterium to evade host immune responses. It consists of alternating units of N-acetylneuraminic acid (Neu5Ac) linked to galactose. Antibodies targeting this polysaccharide confer protection against infection and are the basis for conjugate vaccines.
- Other names
- Group W135 capsular polysaccharideNmW135 CPSW135 polysaccharideSerogroup W135 capsular polysaccharide
02
Mechanism of action
Antibodies targeting the W135 capsular polysaccharide promote complement-mediated killing and opsonization of *Neisseria meningitidis* serogroup W135. Conjugate vaccines induce T-cell dependent immune responses, leading to long-lasting immunity.
03
Biological functions
Immune evasionComplement resistanceInhibition of phagocytosisVirulence factor
04
Disease associations
Invasive meningococcal diseaseMeningitisSepticemia
05
Safety considerations
Vaccine-related adverse events (rare)Potential for reduced vaccine efficacy in certain populationsBreakthrough infections in vaccinated individuals
06
Interacting drugs
Menactra
3 more in the full profile.
07
Biomarkers
Antibody titers against W135 CPSPresence of W135 CPS in blood or cerebrospinal fluid
Beyond the preview
Go deeper on Neisseria meningitidis Group W135 Capsular Polysaccharide (W135 CPS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neisseria meningitidis Group W135 Capsular Polysaccharide (W135 CPS).