Target intelligence / Profile preview

Neisseria meningitidis Group Y Capsular Polysaccharide (Group Y CPS)

Target: Group Y CPS
Molecular classification: Polysaccharide, Capsular Polysaccharide, Antigen

Overview

The Neisseria meningitidis group Y capsular polysaccharide is a complex polysaccharide composed of alternating D-glucose and N-acetylneuraminic acid residues. It is a key virulence factor that enables the bacteria to evade host immune responses. As such it is an important antigen for vaccine development. When conjugated to carrier proteins, it elicits a robust T-cell dependent humoral immune response leading to protective antibody production and preventing invasive disease.

Other names: N. meningitidis serogroup Y capsular polysaccharideGroup Y capsular polysaccharide antigenGroup Y polysaccharideNeisseria meningitidis Y antigen

Mechanism of action

Conjugation with carrier proteins enables T-cell dependent antibody production and opsonization/complement activation upon bacterial exposure.

Biological functions

Immune evasionProtection against complement-mediated killingInhibition of phagocytosisResistance to cationic antimicrobial peptidesBacterial virulence

Disease associations

Invasive meningococcal diseaseMeningitisSepticemia

Safety considerations

Potential for breakthrough infections in vaccinated individuals with waning immunityRare instances of vaccine-related adverse events (e.g., injection site reactions)Capsule switching via horizontal gene transfer leading to vaccine escape

Interacting drugs

Quadrivalent conjugate vaccines (ACYW)

2 more in the full profile.

Biomarkers

Serum IgG antibodies against group Y capsular polysaccharideOpsonophagocytic activity (OPA) titers

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