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Neisseria meningitidis Group Y Polysaccharide Antigen (Group Y Polysaccharide)
- Target
- Group Y Polysaccharide
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Neisseria meningitidis group Y polysaccharide antigen is a capsular polysaccharide found on the surface of N. meningitidis serogroup Y bacteria. This antigen is a key virulence factor, enabling the bacterium to evade host immune responses. It is composed of repeating disaccharide units of D-glucose and N-acetylneuraminic acid linked via α(2→6) linkages, with O-acetylation of the sialic acid. Antibodies targeting this polysaccharide confer immunity and are the basis for vaccines against serogroup Y meningococcal disease.
- Other names
- N. meningitidis Group Y CapsuleGroup Y Capsular PolysaccharideNmY Polysaccharide
02
Mechanism of action
Vaccine-induced antibody production against the polysaccharide leading to opsonization and complement activation, resulting in bacterial clearance.
03
Biological functions
Immune evasionVirulence factorAntigen presentationCapsule formationProtection against phagocytosisInhibition of complement-mediated killing
04
Disease associations
MeningitisMeningococcal diseaseInvasive bacterial infection
05
Safety considerations
Vaccine-related adverse reactions (e.g., injection site pain, fever)Potential for breakthrough infections in vaccinated individuals
06
Interacting drugs
MenACWY vaccines
2 more in the full profile.
07
Biomarkers
Anti-Group Y antibody titersPresence of Group Y N. meningitidis in CSF or blood
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