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Target intelligence / Profile preview
Neisseria meningitidis Outer Membrane Protein (OMP)
- Target
- OMP
- Molecular classification
- Porin, Adhesin, Transporter, Peptidase, Lipoprotein
01
Overview
Neisseria meningitidis outer membrane proteins (OMPs) are surface-exposed proteins crucial for bacterial survival, pathogenesis, and interaction with the host. They serve diverse functions including nutrient transport, adhesion to host cells, immune evasion, and are primary targets for vaccine development. Major classes include porins (PorA, PorB), adhesins (OpcA), transporters (CtrA), peptidases (NMB0315), and lipoproteins. Antibodies against specific OMPs can be bactericidal and protective.
- Other names
- Outer Membrane ProteinN. meningitidis OMPOM proteins
02
Mechanism of action
Antibody-mediated bacterial killing; Inhibition of adhesion/invasion; Disruption of membrane integrity; Blocking of nutrient uptake
03
Biological functions
Nutrient transportAdhesionInvasionImmune evasionCapsule polysaccharide exportBiofilm formationInterbacterial competitionAssembly/stability of outer membrane complexesStress response regulation
04
Disease associations
InfectionMeningococcal disease
05
Safety considerations
Antigenic variability across strainsPotential for immune evasionOff-target effects of broadly acting inhibitors
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