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Target intelligence / Profile preview
Neisseria meningitidis serogroup A capsular polysaccharide (None)
- Target
- None
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is a key virulence factor and the primary antigenic determinant for this serogroup. It forms the basis for classification, epidemiological tracking, and vaccine development against serogroup A meningococcal disease. It is composed of repeating units of O-acetylated (α1→6)-linked N-acetyl-D-mannosamine-1-phosphate (ManNAc-1-P).
02
Mechanism of action
Antibodies targeting the polysaccharide mediate complement-dependent killing or opsonization.
03
Biological functions
Immune evasionProtection against complement-mediated killingInhibition of phagocytosisAntigen presentation
04
Disease associations
InfectionMeningococcal disease
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