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Neisseria meningitidis serogroup A capsular polysaccharide

Molecular classification: Polysaccharide, Capsular Polysaccharide

Overview

The Neisseria meningitidis serogroup A capsular polysaccharide (CPS) is a key virulence factor and the primary antigenic determinant for this serogroup. It forms the basis for classification, epidemiological tracking, and vaccine development against serogroup A meningococcal disease. It is composed of repeating units of O-acetylated (α1→6)-linked N-acetyl-D-mannosamine-1-phosphate (ManNAc-1-P).

Mechanism of action

Antibodies targeting the polysaccharide mediate complement-dependent killing or opsonization.

Biological functions

Immune evasionProtection against complement-mediated killingInhibition of phagocytosisAntigen presentation

Disease associations

InfectionMeningococcal disease

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