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Neisseria meningitidis Serogroup B Antigen
- Molecular classification
- Bacterial Antigen, Polysaccharide Capsule, Outer Membrane Protein, Lipoprotein
01
Overview
Neisseria meningitidis serogroup B (MenB) is a Gram-negative encapsulated bacterium responsible for invasive diseases. The capsule is poorly immunogenic, so vaccines target surface-exposed proteins: Factor H binding protein (fHbp), Neisserial heparin binding antigen (NHBA), Neisseria adhesin A (NadA), and PorA. Vaccines like 4CMenB (Bexsero) and Trumenba induce bactericidal antibodies to prevent disease.
- Other names
- MenB AntigenGroup B Meningococcal AntigenfHbpNHBANadAPorA
02
Mechanism of action
Vaccine antigens stimulate the production of bactericidal antibodies against Neisseria meningitidis serogroup B, primarily targeting surface-exposed proteins like fHbp, NHBA, NadA, and PorA.
03
Biological functions
Capsule formationImmune evasionAdhesion to host cellsComplement bindingNutrient Acquisition
04
Disease associations
InfectionMeningitisSepticemiaInvasive Meningococcal Disease
05
Safety considerations
Antigenic variability requires broad cross-reactivity or multicomponent formulations.Capsular mimicry of human molecules leads to poor natural immunity.
06
Interacting drugs
4CMenB (Bexsero)
1 more in the full profile.
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