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Target intelligence / Profile preview
Neisseria meningitidis Group B Surface Proteins (MenB Surface Proteins)
- Target
- MenB Surface Proteins
- Molecular classification
- Outer Membrane Protein, Porin, Adhesin
01
Overview
Neisseria meningitidis group B (MenB) surface proteins are critical for the bacterium’s ability to colonize, evade host immunity, and cause meningitis and sepsis. Key proteins include factor H binding protein (fHbp), Neisserial surface protein A (NspA), and porins PorA & PorB. These proteins mediate adherence, complement inhibition, and induction of protective antibody responses. Current MenB vaccines rely on combinations of these conserved surface-exposed proteins due to poor immunogenicity of the group B capsule.
- Other names
- MenB Surface AntigensNeisseria meningitidis serogroup B outer membrane proteins
02
Mechanism of action
Induction of bactericidal antibodies
03
Biological functions
AdherenceNutrient uptakeComplement evasionImmune evasionColonization
04
Disease associations
MeningitisSepsisInfection
05
Safety considerations
Antigenic variabilityStrain-specific efficacy
06
Interacting drugs
Bexsero (vaccine)
1 more in the full profile.
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