Neisseria meningitidis serogroup B surface antigen (None standardized)

Neisseria meningitidis serogroup B surface antigens are a group of outer membrane-associated proteins expressed by the serogroup B strains of Neisseria meningitidis, a Gram-negative bacterial pathogen responsible for invasive meningococcal disease, including meningitis and septicemia. Key surface antigens include factor H binding protein (fHbp), Neisseria adhesin A (NadA), Neisseria heparin binding antigen (NHBA), and Porin A protein (PorA P1.4). These antigens enable immune evasion, mediate adherence to host tissues, and contribute to bacterial virulence. They serve as the primary targets for modern recombinant vaccines (e.g., 4CMenB/Bexsero, MenB-FHbp/Trumenba), which elicit protective antibody responses and provide immunity by complement-mediated bactericidal activity. Strain coverage and vaccine effectiveness depend on the presence and expression of these antigens in circulating MenB strains.

Other names

MenB surface antigensMeningococcal B surface antigensNeisseria meningitidis group B surface antigensfHbp (factor H binding protein)NHBA (Neisseria heparin binding antigen)NadA (Neisseria adhesin A)PorA P1.4 (Porin A protein, subtype P1.4)

Vaccine-induced antibody responses trigger complement-mediated killing of N. meningitidis serogroup B by binding to surface antigens, leading to bacterial lysis and/or opsonization. Neutralization of bacterial adhesion and immune evasion functions (e.g., blocking fHbp-human factor H interaction, targeting NadA/NHBA-mediated adhesion).