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Target intelligence / Profile preview
Neisseria meningitidis Serogroup C Capsular Polysaccharide (NmC CPS)
- Target
- NmC CPS
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Bacterial Antigen
01
Overview
The capsular polysaccharide of *Neisseria meningitidis* serogroup C is a homopolymer composed of sialic acid (N-acetylneuraminic acid) residues linked by α(2→9) glycosidic bonds. It may be partially O-acetylated. The capsule is a major virulence factor, providing resistance against antibody/complement-mediated killing and phagocytosis. It is a key target for vaccine development. Serogroup C strains are commonly associated with invasive meningococcal disease, and vaccines targeting this capsule are widely used for prevention. Capsule switching can occur, allowing for immune evasion.
- Other names
- Serogroup C Capsular PolysaccharideGroup C Meningococcal PolysaccharideNmC Polysaccharide
02
Mechanism of action
Vaccines induce antibodies that promote complement-mediated killing and opsonophagocytosis of bacteria expressing the serogroup C capsule.
03
Biological functions
Immune evasionVirulence factorCapsule biosynthesisAdhesion
04
Disease associations
Invasive Meningococcal DiseaseMeningitisSepticemia
05
Safety considerations
Capsule switchingVariable immunogenicityO-acetylation variability
06
Interacting drugs
Serogroup C Meningococcal Conjugate Vaccines
1 more in the full profile.
07
Biomarkers
Capsular polysaccharide levels in CSF/bloodAnti-capsular antibody titers
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