Neisseria meningitidis serogroup C capsular polysaccharide antigen-conjugated protein carrier

The Neisseria meningitidis serogroup C capsular polysaccharide antigen-conjugated protein carrier is a vaccine component designed to prevent invasive disease caused by N. meningitidis serogroup C. The capsular polysaccharide, a key virulence factor, is conjugated to a protein carrier (typically tetanus toxoid or CRM197) to enhance immunogenicity, particularly in infants and young children. This conjugation converts the polysaccharide into a T cell-dependent antigen, leading to robust antibody production, immunological memory, and long-lasting protection against the disease.

Other names

MenC conjugate vaccineSerogroup C meningococcal conjugate vaccine

Elicits a T-cell dependent immune response by conjugating the N. meningitidis serogroup C capsular polysaccharide to a protein carrier (e.g., tetanus toxoid, CRM197). This leads to B-cell activation, antibody production (including IgG), and long-term immunological memory, providing protection against invasive disease caused by N. meningitidis serogroup C.