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Target intelligence / Profile preview
Neisseria meningitidis serogroup C polysaccharide antigen-conjugate complex (MenC conjugate vaccine)
- Target
- MenC conjugate vaccine
- Molecular classification
- Polysaccharide-protein conjugate, Vaccine component
01
Overview
The Neisseria meningitidis serogroup C polysaccharide antigen-conjugate complex is a vaccine component designed to prevent invasive disease caused by Neisseria meningitidis, specifically targeting the serogroup C strain. This target molecule consists of the capsular polysaccharide from N. meningitidis serogroup C covalently linked (conjugated) to a carrier protein, most commonly CRM197 (a non-toxic mutant of diphtheria toxin), tetanus toxoid, or diphtheria toxoid. Conjugation to a protein carrier transforms the immune response to T-cell dependent, resulting in improved immunogenicity, especially in infants and young children. Conjugate vaccines induce immunologic memory and provide herd immunity by reducing nasopharyngeal carriage.
- Other names
- MenC conjugate vaccineSerogroup C meningococcal conjugate vaccineNeisseria meningitidis serogroup C conjugate vaccine
02
Mechanism of action
Induction of anti-capsular polysaccharide antibodies via T-cell dependent B-cell activation.
03
Biological functions
Antigen presentationImmune response inductionAntibody productionImmunological memory
04
Disease associations
InfectionMeningococcal diseaseMeningitisSepticemia
05
Safety considerations
Local injection site reactionsFever
06
Interacting drugs
Menjugate®
4 more in the full profile.
07
Biomarkers
Anti-capsular polysaccharide antibody titersSeroprotection rate
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