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Target intelligence / Profile preview
Neisseria meningitidis Serogroup C Polysaccharide Capsule (Serogroup C Capsule)
- Target
- Serogroup C Capsule
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The polysaccharide capsule of Neisseria meningitidis serogroup C is a major virulence factor composed of α(2→9)-linked sialic acid (N-acetylneuraminic acid) homopolymers. It protects the bacterium from complement-mediated lysis and phagocytosis, enabling systemic infection. The genes responsible for its synthesis are clustered in the cps locus. It is a key target for conjugate vaccines, which have proven effective in reducing disease incidence.
- Other names
- N. meningitidis Serogroup C CapsuleGroup C Polysaccharide CapsuleSerogroup C Capsular PolysaccharidePolysialic acid (α(2→9)-linked N-acetylneuraminic acid) capsule
02
Mechanism of action
Antibody-mediated opsonization and complement activation following vaccination
03
Biological functions
Immune evasionComplement inhibitionProtection from phagocytosisVirulence factorCapsule biogenesis and translocation
04
Disease associations
MeningitisSepticemiaInvasive meningococcal diseaseInfection
05
Safety considerations
Guillain-Barré syndrome (rare)Injection site reactions
06
Interacting drugs
Conjugate vaccines (e.g., MenC conjugate vaccine)
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