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Target intelligence / Profile preview
Neisseria meningitidis serogroup W capsular polysaccharide antigen-conjugated protein carrier
- Molecular classification
- Polysaccharide antigen, Protein conjugate
01
Overview
The capsular polysaccharide antigen from Neisseria meningitidis serogroup W, chemically conjugated to a protein carrier (e.g., CRM197 or outer membrane proteins). This construct is used in vaccines to enhance immunogenicity and elicit a protective antibody response against invasive disease caused by serogroup W strains. Conjugation converts the T-cell-independent polysaccharide antigen into a T-cell-dependent antigen, resulting in improved immune responses, particularly in infants and young children.
- Other names
- Serogroup W polysaccharide-protein conjugateN. meningitidis serogroup W conjugate vaccine antigen
02
Mechanism of action
Stimulates T-cell dependent antibody production against the N. meningitidis serogroup W capsular polysaccharide
03
Biological functions
Evasion of host immunityInduction of protective antibody responseVaccine antigen
04
Disease associations
InfectionMeningococcal disease
05
Safety considerations
Local injection site reactionsRare cases of allergic reactions
06
Interacting drugs
Meningococcal conjugate vaccines (e.g., MenACWY)
07
Biomarkers
Anti-capsular polysaccharide antibody titersOpsonophagocytic activity (OPA) assay results
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