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Target intelligence / Profile preview
Neisseria meningitidis serogroup W capsular polysaccharide conjugate antigen
- Molecular classification
- Polysaccharide, Conjugate antigen
01
Overview
The Neisseria meningitidis serogroup W capsular polysaccharide conjugate antigen is a component of several quadrivalent meningococcal vaccines (MenACWY), which are designed to protect against invasive disease caused by four major serogroups of N. meningitidis: A, C, W, and Y. The antigen consists of the capsular polysaccharide from serogroup W chemically linked (conjugated) to a carrier protein—commonly CRM197, a non-toxic mutant of diphtheria toxin—to enhance immunogenicity. Conjugation enhances immunogenicity by inducing robust antibody production even in populations with immature immune systems (infants/young children), generating memory B cells for long-term protection and reducing nasopharyngeal carriage and thus transmission within populations.
- Other names
- MenW capsular polysaccharide conjugate antigenSerogroup W polysaccharide-CRM197 conjugateMenW antigen
02
Mechanism of action
Induces production of anti-capsular polysaccharide antibodies
03
Biological functions
AntigenImmune response inductionB cell activationAntibody production
04
Disease associations
InfectionMeningococcal disease
05
Safety considerations
Allergic reactions to vaccine componentsReduced response in immunocompromised individualsLack of protection against non-vaccine serogroups
06
Interacting drugs
MenACWY vaccines
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