Neisseria meningitidis serogroup W135 (N. meningitidis W135)

Neisseria meningitidis serogroup W135 is a subgroup of *Neisseria meningitidis* characterized by its specific capsular polysaccharide. It is a Gram-negative, encapsulated diplococcus found in the family Neisseriaceae. W135 is distinguished by molecular typing and is part of the clonal complex ST-11, responsible for significant global outbreaks, including a well-known epidemic during the Hajj in 2000[2][5][8]. This serogroup is a leading cause of invasive meningococcal disease, presenting primarily as meningitis and sepsis, and is associated with high mortality and morbidity worldwide[3][7][9]. Surveillance and vaccination programs are critical for management due to its rapid disease progression and potential for antibiotic resistance[1][5][9].

Other names

Meningococcus W135MenW135N. meningitidis W135Meningococcal group WEpidemic clone ST-11 W135

Bactericidal inhibition of cell wall synthesis (β-lactams: penicillins, cephalosporins) Blockage of nucleic acid synthesis (rifampin, ciprofloxacin) Immunization-induced antibody production (vaccine)