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Target intelligence / Profile preview
Neisseria meningitidis serogroup W135 polysaccharide antigen-conjugate complex (W135-conjugate)
- Target
- W135-conjugate
- Molecular classification
- Polysaccharide, Conjugate Vaccine Component
01
Overview
The Neisseria meningitidis serogroup W135 polysaccharide antigen-conjugate complex is a vaccine component designed to prevent invasive disease caused by Neisseria meningitidis serogroup W-135. The target molecule is the capsular polysaccharide specific to the W-135 serogroup, chemically conjugated to a carrier protein (diphtheria toxoid, CRM197 or tetanus toxoid) to enhance immunogenicity. This conjugation transforms the polysaccharide into a T-cell dependent antigen, eliciting robust IgG responses and immunological memory.
- Other names
- Meningococcal group W-135 capsular antigenNeisseria meningitidis group w-135 capsular polysaccharide diphtheria conjugateNeisseria meningitidis group w-135 capsular polysaccharide tetanus conjugateNeisseria meningitidis group w-135 capsular polysaccharide CRM197 conjugate
02
Mechanism of action
Induction of anti-capsular polysaccharide IgG antibodies via T-cell dependent B-cell activation.
03
Biological functions
Antigen presentationImmune response inductionB-cell activationT-cell activationAntibody productionImmunological memory
04
Disease associations
InfectionMeningococcal diseaseMeningitisSepticemia
05
Safety considerations
Local injection site reactionsFeverRare allergic reactions
06
Interacting drugs
Menactra
3 more in the full profile.
07
Biomarkers
Anti-W135 capsular polysaccharide IgG antibody titersSerum bactericidal activity (SBA)
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